🔬 LongevLife Research Center

The LongevLife Research Center
for Longevity

Verified
Longevity Research Library

Every study is real. Every DOI is verified. Every citation is independently verifiable via PubMed. Zero fabrications.

✓ Zero Fabricated Citations ✓ DOI Links Provided ✓ Peer Reviewed Only ✗ No Invented Authors ✗ No Fake Statistics
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Tier-1 Journals New England Journal of Medicine The Lancet Nature Communications Science Cell Metabolism PNAS JACC Hypertension Exp. Gerontology Nutrients Lancet Psychiatry Aging (Albany NY)
12 Research Categories
Full Research Library
12 research areas · 30+ articles · DOI-verified research
LongevLife Research Library - 12 scientific categories
NMN / NAD+ Omega-3 Creatine CoQ10 Magnesium Biological Age HRV Inflammation Exercise Fasting Hormones Brain Health
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30 Categories
IF 158.5 Evidence 96-98 3 Studies
GLP-1 Agonists and Metabolic Health
GLP-1 Receptor Agonists & Metabolic Health
SELECT, STEP-1, and SURMOUNT-1 trials from NEJM 2021-2023. SELECT (n=17,604): a 20% reduction in cardiovascular risk in obese patients. STEP-1 (n=1,961): an average 14.9% weight loss. SURMOUNT-1 (n=2,539): up to 20.9% loss.
NEJM · 2021 · 2022 · 2023 Read more →
IF 11.1 Evidence 91-93 2 Studies
The Science of Biological Age
Biological Age Science
Belsky et al. (PNAS, n=954): biological age can be quantified by age 26. Lu et al. (Aging, n=13,000): GrimAge predicts mortality better than any single marker.
PNAS 2015 · Aging 2019 Read more →
IF 158.5 Evidence 96 1 Study
Vitamin D and Longevity
Vitamin D & Longevity
VITAL Trial (Manson et al., NEJM 2019, n=25,871): D3 2000 IU reduced cancer mortality by 25% (RR 0.75). The largest trial ever conducted on vitamin D.
NEJM · Manson 2019 Read more →
IF 56.9 Evidence 73-88 3 Studies
NMN / NAD+ and Longevity
NMN / NAD+ & Longevity
Yoshino et al. (Science 2021, n=25): the first human RCT; NMN improved insulin sensitivity. Mills et al. (Cell Metabolism 2016): key pre-clinical evidence.
Science · Cell Metabolism Read more →
IF 16.6 Evidence 91 1 Study
Sleep and Biological Aging
Sleep & Biological Aging
Sabia et al. (Nature Communications 2021, n=7,959): sleeping ≤6 hours at ages 50-60 increases dementia risk by 30%.
Nature Communications · Sabia 2021 Read more →
IF 168.9 Evidence 94 1 Study
HbA1c and Metabolic Aging
HbA1c & Metabolic Aging
Lancet Meta-analysis (n=310,458): HbA1c above 5.4% is linked to increased mortality even within the "normal" range. The largest on this topic.
The Lancet · n=310,458 Read more →
IF 8.0 Evidence 77-82 2 Studies
Magnesium and Biological Aging
Magnesium & Biological Aging
Rodríguez-Morán (Hypertension, 2014): improvement in metabolic syndrome. Arab et al. (2023): improved sleep quality via GABA and melatonin. 45-50% of the Western population are deficient.
Hypertension · Nutrients Read more →
IF 5.9 Evidence 78-82 2 Studies
Creatine and Longevity
Creatine & Longevity
Avgerinos et al. (Exp Gerontology, 2018): improved short-term memory. Smith-Ryan et al. (Nutrients, 2021): unique benefits for women across the life cycle.
Exp Gerontology · Nutrients Read more →
IF 8.3 Evidence 87 1 Study
ApoB and Cardiovascular Risk
ApoB & Cardiovascular Longevity
Sniderman et al. (JACC, 2019): ApoB is superior to LDL-C for risk prediction. Longevity target: <70 mg/dL. כל חלקיק נושא בדיוק ApoB אחד.
JACC · Sniderman 2019 Read more →
IF 64.3 Evidence 84-88 1 Study
Brain Fog and Cognitive Health
Brain Fog & Cognitive Longevity
Rogers et al. (Lancet Psychiatry, 2020): neuroinflammation as a basis for brain fog. VITAL omega-3 sub-study: a cognitive-protection signal.
Lancet Psychiatry · NEJM Read more →
IF 158.5 Evidence 88 1 Study
Omega-3 and Longevity
Omega-3 & Longevity
VITAL (Manson et al., NEJM 2019, n=25,871): omega-3 reduced MI by 28% (RR 0.72, P=0.03). Omega-3 Index >8% Longevity target.
NEJM · VITAL 2019 Read more →
Evidence 85
Physical Activity and Longevity
Exercise & Longevity
Zone 2 Training, strength training, VO2max - the three pillars of healthspan. Zone 2: mitochondrial biogenesis.
Meta-analyses · RCTsRead more →
Evidence 88
VO2max and Lifespan
VO2max & Longevity
The strongest predictor of mortality. Every 1 MET increase = a 13% reduction in all-cause mortality.
JACC · JAMARead more →
Evidence 85
Muscle Mass and Longevity
Muscle Mass & Longevity
Sarcopenia - 0.5-1% muscle loss per year from age 30. Predicts mortality and functional independence.
Age Ageing · Exp GerontologyRead more →
Evidence 85
Chronic Inflammation and Longevity
Inflammation & Aging
Inflammaging - a central mechanism in aging. CRP, IL-6, and TNF-alpha are key markers.
Nat Rev Immunol · Aging CellRead more →
Evidence 82
Women's Health and Longevity
Women's Health & Longevity
MRS (Menopause Rating Scale) - a tool validated in 23 languages. Hormonal changes affect all Longevity markers.
Climacteric · MenopauseRead more →
Evidence 80
Intermittent Fasting and Longevity
Intermittent Fasting
Autophagy - cellular cleanup. mTOR inhibition. Insulin sensitivity. 16:8, 5:2, TRE - different methods with different evidence.
Cell Metabolism · NEJMRead more →
Evidence 80
Stress and Biological Age
Stress & Biological Aging
Chronic cortisol accelerates telomere shortening, increases inflammation, and impairs sleep. Low HRV = chronic stress.
PsychoneuroendocrinologyRead more →
Evidence 78
Gut Health and Longevity
Gut Health & Longevity
The gut microbiome affects immunity, inflammation, and metabolism. Gut-Brain Axis. Leaky Gut = systemic inflammation.
Nature · Cell Host MicrobeRead more →
Evidence 85
HRV & Health
HRV & Health
Heart rate variability - a measure of the autonomic nervous system's flexibility. Predicts mortality. Oura Ring and Apple Watch.
Frontiers Physiology · JACCRead more →
Cardiovascular Health · Longevity Research
Cardiovascular disease is the #1 cause of death worldwide. The SELECT trial (NEJM, 2023): semaglutide reduced cardiovascular events by 20% in obese patients. Key markers: ApoB, CRP,
Read more →
Focus & Cognition · Longevity Research
Cognitive decline begins on average at age 30, usually without noticeable symptoms. Avgerinos et al. (2018): creatine improves short-term memory. Mg L-Threonate is the only form that crosses the blood-brain barrier
Read more →
The Science of Longevity · Longevity Research
Extending healthspan (healthy lifespan) rests on the 9 Hallmarks of Aging: genomic instability, telomere attrition, epigenetic alterations, proteosta
Read more →
Metabolic Health · Longevity Research
Metabolic health - maintaining insulin sensitivity, normal glucose, healthy lipids, and low CRP is the foundation of a young biological age. About 88% of adults in the US
Read more →
NAD+ & Longevity Pathways · Longevity Research
NAD+ activates Sirtuins (SIRT1-7), PARPs (DNA repair), and CD38. Key NAD+ pathways: biosynthesis from Tryptophan, Nicotinamide, NMN, and NR. All pathways converge on maintaining
Read more →
Protein & Longevity · Longevity Research
Protein is the foundation for preserving muscle - the single most important factor for healthspan. 1.6-2.2 g/kg
Read more →
Recovery & Fitness · Longevity Research
Recovery is an inseparable part of training. Without sleep, nutrition, and stress management, training creates load without benefit. HRV is the clearest measure of recovery quality.
Read more →
Evidence Methodology
01
Study Design (40%)
RCTs > Meta-analyses > Cohorts. No opinion pieces.
02
Sample Size (25%)
Large trials (>1,000) score highest.
03
Journal Quality (20%)
Tier-1 only. Impact Factor verified.
04
Clinical Relevance (15%)
Applicable to healthy aging. Effect sizes matter.
05
Publication Recency
Last 5 years priority. Landmark older studies noted.
06
Zero Fabrication
Unverifiable = excluded. Fewer, all real.
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Transparency Note
This center deliberately includes fewer studies than you might expect, because we prioritize accuracy over quantity. Every DOI and PubMed link is independently verifiable. If a study cannot be verified, it is not included - even if it would strengthen the argument. Read our citation policy →