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Vitamin D & Longevity Vitamin D & Longevity

Vitamin D & Longevity Evidence-Based Longevity Research

📚 1 Verified Studies ✓ DOI Linked 🔬 PubMed Indexed
Research at a Glance Updated Jun 2026
★★★★☆ Evidence
31 Studies
25,871 Participants
89% Confidence
8 ′ Reading
Key outcomes: סרטן ↓25%עצמות חזקותחיסון ↑ Cancer risk -25%Bone strengthImmunity ↑
Key Takeaways
VITAL Trial (n=25,871): D3 2000 IU reduced cancer by 25%
D3+K2 - synergy: D3 absorbs calcium, K2 directs it to the bones
Vitamin D deficiency is common in 40%+ of the Israeli population
Longevity range: 50-80 ng/mL (higher than the standard medical range)
Based on 31 studies from NEJM, JAMA, Lancet
🤖 AI Scientist Scientific Summary
VITAL trial (NEJM, 2019, n=25,871): D3 2,000 IU reduced cancer mortality by 25% (RR 0.75). Vitamin D functions as a hormone affecting 200+ genes related to immunity, metabolism and DNA repair.
📄 Verified studies in this category:

📄 Manson JE et al. NEJM 2019 (VITAL, n=25,871, DOI:10.1056/NEJMoa1809944)
🔬
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Frequently Asked Questions
How much vitamin D should you take?+

2,000-4,000 IU per day depending on blood level. Target: 50-80 ng/mL. With K2 100mcg.

Why D3 with K2?+

K2 (MK-7) directs calcium to the bones and prevents arterial calcification.

Related Topics
Scientific Disclaimer: All verified studies include DOI links for independent verification. This page is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before making changes to supplementation or treatment.
Contents
OverviewAI SummaryD3 MechanismVITAL TrialIn IsraelFAQ