All Medications
All Medications
Click a medication for the full guide
Click a drug for the full guide
Dosages, side effects, protocol, price, and research - for each medication separately.
Dosing, side effects, protocol, pricing and research - for each drug separately.
SELECT Trial ยท NEJM 2023 ยท Longevity-Changing Research
The breakthrough: GLP-1 protects the heart directly
The Breakthrough: GLP-1 Directly Protects the Heart
Lincoff AM et al. - 17,604 obese patients without diabetes. Semaglutide 2.4mg reduced major cardiovascular events by 20% (HR 0.80, P<0.001). The finding: the protection appeared before significant weight loss - suggesting a direct cardioprotective mechanism of GLP-1 on the heart, beyond weight loss.
Lincoff AM et al. - 17,604 obese patients without diabetes. Semaglutide 2.4mg reduced major cardiovascular events by 20% (HR 0.80, P<0.001). Key finding: protection appeared before significant weight loss - suggesting direct cardioprotective mechanisms beyond weight loss.
17,604ParticipantsParticipants
โ20%Cardio riskCardio risk
5 YearsyearsFollow-upFollow-up
DOI: 10.1056/NEJMoa2307563 โ
ืคืคืืืืื
Peptides
ืืขืืจ ืืืืจ ืื ืืืื
Beyond the current generation
ืื ืืชืจืืคืืช ืฉืืืขืื ืื ืคืคืืืืื. ืืืงื ืืืืฉืจืืช, ืืืจืืช ืขืืืื ืื ืืกืืืื ืงืืื ืืื, ืืืฉ ืืืื ืฉื ืืืจืืช ืืจืฉืช ืืื ืื ืคืืงืื.
Every medication above is a peptide. Some are approved, others are still in clinical trials, and some are sold online with no oversight at all.
ืคืคืืืืื ืืจืืืจืืืืื
Peptides and retatrutide
ืื ืื ืื ืื, ืกืืืืก ืจืืืืืืจื, ืืกืืืื ื ืจืืืฉื ืขืฆืืืืช ืืจืฉืช
Mechanisms, regulatory status, and the risks of buying online
FAQ
Frequently Asked Questions
What is the difference between Ozempic and Wegovy?What's the difference between Ozempic and Wegovy?+
Both contain Semaglutide. Ozempic up to 2mg - approved for type 2 diabetes. Wegovy 2.4mg - approved for weight management. Wegovy's higher dose leads to greater weight loss (14.9% vs 4-6%).
Both contain Semaglutide. Ozempic up to 2mg - approved for type 2 diabetes. Wegovy 2.4mg - approved for weight management. The higher Wegovy dose produces greater weight loss (14.9% vs 4-6%).
Mounjaro vs Ozempic - which is more effective?Mounjaro vs Ozempic - which is more effective?+
Mounjaro (Tirzepatide) is more effective for weight loss: up to 20.9% vs 14.9% for Wegovy. Mounjaro is a dual agonist - GLP-1 + GIP. The SURMOUNT-5 trial (2024) demonstrated Tirzepatide's superiority. However: Ozempic has the proven SELECT trial (cardiovascular protection). Full comparison here โ
Mounjaro (Tirzepatide) is more effective for weight loss: up to 20.9% vs 14.9% for Wegovy. Mounjaro is a dual agonist - GLP-1 + GIP. SURMOUNT-5 (2024) confirmed Tirzepatide superiority. But: Ozempic has the proven SELECT trial (cardiovascular protection). Full comparison here โ
What happens when you stop taking GLP-1?What happens when stopping GLP-1?+
STEP-4 (NEJM 2021): after stopping, on average 2/3 of the lost weight returns within a year. GLP-1 treats the symptom (high appetite), not the cause. Lifestyle change - Zone 2, nutrition, sleep - during treatment is critical for maintaining long-term results.
STEP-4 study (NEJM 2021): after stopping, on average 2/3 of lost weight returns within one year. GLP-1 treats the symptom (elevated appetite), not the root cause. Lifestyle changes - Zone 2, diet, sleep - during treatment are critical for long-term results.
Is GLP-1 safe long-term?Are GLP-1 medications safe long-term?+
SELECT followed patients for 5 years with no new safety signals. Common effects: nausea (44%), diarrhea (30%) - most resolve within 4-8 weeks. Rare effects: pancreatitis (a small increase). Important: close medical supervision, especially in the first year.
SELECT followed patients for 5 years with no new safety signals. Common effects: nausea (44%), diarrhea (30%) - most resolve within 4-8 weeks. Rare: pancreatitis (small increased risk). Important: close medical supervision, especially in the first year.
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Important Medical Disclaimer
Important Medical Disclaimer
All GLP-1 medications require a doctor's prescription. The information on this site is for educational purposes only and does not constitute medical advice, diagnosis, or a substitute for medical care. Consult a physician before any change. Dosages and side effects vary between individuals.
All GLP-1 medications require a physician's prescription. Information is for educational purposes only and does not constitute medical advice, diagnosis or treatment. Consult a physician before any changes. Dosing and side effects vary between individuals.