๐Ÿ’Š GLP-1 Library ยท LongevLife

Medications GLP-1
The Complete 2025 Guide

GLP-1 Medications
Complete Guide 2025

Ozempic, Wegovy, Mounjaro, Rybelsus - dosing, side effects, comparisons and verified research. Every DOI verifiable.

Semaglutide Tirzepatide GLP-1 / GIP FDA Approved DOI Verified
4Drugs
3NEJM RCTs
57K+Participants
-20%Cardio risk
All Medications
Click a drug for the full guide

Dosing, side effects, protocol, pricing and research - for each drug separately.

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FDA Approved โœ“
Ozempic
Semaglutide 0.5 / 1 / 2mg ยท Weekly injectionWeekly injection
GLP-1 RA FDA 2017
โˆ’4.6% Mean weight loss (1mg)
๐Ÿ’Š
Private
Wegovy
Semaglutide 2.4mg ยท Weekly injection ยท Weight managementWeekly injection ยท Weight management
GLP-1 RA FDA 2021
โˆ’14.9% STEP-1 ยท n=1,961 ยท NEJM 2021
โšก
Most effective available
Mounjaro
Tirzepatide 5 / 10 / 15mg ยท Weekly injectionWeekly injection
GLP-1 RA GIP RA FDA 2022
โˆ’20.9% SURMOUNT-1 ยท n=2,539 ยท NEJM 2022
๐Ÿ’Š
FDA Approved โœ“
Rybelsus
Semaglutide 3 / 7 / 14mg ยท Daily pillDaily pill
GLP-1 RA First oral GLP-1
โˆ’4.2% Oral version - no injections
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Ozempic vs. Mounjaro
Which is more effective? Safer? Who should take each?
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โš ๏ธ
GLP-1 Side Effects Guide
Nausea, Ozempic Face, hair loss - what's real and how to manage
โ†’
SELECT Trial ยท NEJM 2023 ยท Longevity-Changing Research
The Breakthrough: GLP-1 Directly Protects the Heart

Lincoff AM et al. - 17,604 obese patients without diabetes. Semaglutide 2.4mg reduced major cardiovascular events by 20% (HR 0.80, P<0.001). Key finding: protection appeared before significant weight loss - suggesting direct cardioprotective mechanisms beyond weight loss.

17,604Participants
โˆ’20%Cardio risk
5 YearsyearsFollow-up
DOI: 10.1056/NEJMoa2307563 โ†—
Peptides
Beyond the current generation

Every medication above is a peptide. Some are approved, others are still in clinical trials, and some are sold online with no oversight at all.

๐Ÿงช
Investigational
Peptides and retatrutide
Mechanisms, regulatory status, and the risks of buying online
Frequently Asked Questions
What is the difference between Ozempic and Wegovy?What's the difference between Ozempic and Wegovy?+

Both contain Semaglutide. Ozempic up to 2mg - approved for type 2 diabetes. Wegovy 2.4mg - approved for weight management. Wegovy's higher dose leads to greater weight loss (14.9% vs 4-6%).

Both contain Semaglutide. Ozempic up to 2mg - approved for type 2 diabetes. Wegovy 2.4mg - approved for weight management. The higher Wegovy dose produces greater weight loss (14.9% vs 4-6%).

Mounjaro vs Ozempic - which is more effective?Mounjaro vs Ozempic - which is more effective?+

Mounjaro (Tirzepatide) is more effective for weight loss: up to 20.9% vs 14.9% for Wegovy. Mounjaro is a dual agonist - GLP-1 + GIP. The SURMOUNT-5 trial (2024) demonstrated Tirzepatide's superiority. However: Ozempic has the proven SELECT trial (cardiovascular protection). Full comparison here โ†’

Mounjaro (Tirzepatide) is more effective for weight loss: up to 20.9% vs 14.9% for Wegovy. Mounjaro is a dual agonist - GLP-1 + GIP. SURMOUNT-5 (2024) confirmed Tirzepatide superiority. But: Ozempic has the proven SELECT trial (cardiovascular protection). Full comparison here โ†’

What happens when you stop taking GLP-1?What happens when stopping GLP-1?+

STEP-4 (NEJM 2021): after stopping, on average 2/3 of the lost weight returns within a year. GLP-1 treats the symptom (high appetite), not the cause. Lifestyle change - Zone 2, nutrition, sleep - during treatment is critical for maintaining long-term results.

STEP-4 study (NEJM 2021): after stopping, on average 2/3 of lost weight returns within one year. GLP-1 treats the symptom (elevated appetite), not the root cause. Lifestyle changes - Zone 2, diet, sleep - during treatment are critical for long-term results.

Is GLP-1 safe long-term?Are GLP-1 medications safe long-term?+

SELECT followed patients for 5 years with no new safety signals. Common effects: nausea (44%), diarrhea (30%) - most resolve within 4-8 weeks. Rare effects: pancreatitis (a small increase). Important: close medical supervision, especially in the first year.

SELECT followed patients for 5 years with no new safety signals. Common effects: nausea (44%), diarrhea (30%) - most resolve within 4-8 weeks. Rare: pancreatitis (small increased risk). Important: close medical supervision, especially in the first year.

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Important Medical Disclaimer
Important Medical Disclaimer

All GLP-1 medications require a doctor's prescription. The information on this site is for educational purposes only and does not constitute medical advice, diagnosis, or a substitute for medical care. Consult a physician before any change. Dosages and side effects vary between individuals.

All GLP-1 medications require a physician's prescription. Information is for educational purposes only and does not constitute medical advice, diagnosis or treatment. Consult a physician before any changes. Dosing and side effects vary between individuals.